IFNAR1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1, also known as AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC), located on 21q22.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 63525 Da protein composed of 557 amino acids. IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Diseases such as Hepatitis C and Yellow Fever are associated with IFNAR1. The related pathways of IFNAR1 include Immune response IFN alpha/beta signaling pathway and Immune response Role of DAP12 receptors in NK cells.

IFNAR1 Protein (7)

    IFNAR1 Antibody (15)

      IFNAR1 ELISA Kit & Match Antibody ELISA Pair Set (2)

      IFNAR1 cDNA Clone (41)


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      IFNAR1 Lysate (7)

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        IFNAR1 Background

        Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

        IFNAR1 References

        • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
        • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
        • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.

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