ICOS Proteins, cDNA Clones Research Reagents

ICOS (Inducible T Cell Costimulator, also known as AILIM; CD278; CVID1), located on 2q33.2, is a Protein Coding gene. The gene produces a 22625 Da protein composed of 199 amino acids. The ICOS gene encodes inducible T-cell costimulator, a receptor found on the surface of T cells. The corresponding ligand is encoded by the ICOSLG gene. ICOS amino acid sequence shares 24% and 17% identity, respectively, with CD28 and CTLA4. Diseases such as Immunodeficiency, Common Variable, 1, and Common Variable Immunodeficiency are associated with ICOS.

ICOS Protein (10)

    ICOS cDNA Clone (40)

    NM_012092.2
    NM_017480.2
    NM_022610.1
    XM_005574018.1

    In cloning vector

    ICOS Lysate (7)

      ICOS Background

      Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4, and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which are essential for the germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. Also, ICOS is more potent in the induction of IL-10 production, a cytokine important for the suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provide key second signals that can regulate the activation, inhibition, and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested as being involved in the development of airway inflammation and airway hyperresponsiveness.

      ICOS References

      • Coyle AJ, et al. (2004) The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Semin Immunopathol. 25(3-4): 349-59.
      • Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
      • van Berkel ME, et al. (2006) CD28 and ICOS: similar or separate costimulators of T cells Immunol Lett. 105(2): 115-22.

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