Galectin 3/LGALS3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LGALS3 (Galectin 3, also known as L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2), located on 14q22.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 26152 Da protein composed of 250 amino acids. This gene encodes a member of the galectin family of carbohydrate-binding proteins. Diseases such as Follicular Adenoma and Papillary Carcinoma are associated with LGALS3. The related pathways of LGALS3 include Cell adhesion_Cell-matrix glycoconjugates and the Innate Immune System.

All Galectin 3/LGALS3 Reagents

Galectin 3/LGALS3 Protein (2)

    Galectin 3/LGALS3 Antibody (8)

      Galectin 3/LGALS3 ELISA Kit & Match Antibody ELISA Pair Set (1)

      Galectin 3/LGALS3 cDNA Clone (60)

      Galectin 3/LGALS3 Lysate (1)

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        Galectin 3/LGALS3 Background

        LGALS3 (Galectin 3) is a Protein Coding gene. This gene encodes a member of the galectin family of carbohydrate-binding proteins. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. LGALS3 is a beta-galactoside-binding lectin and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion, and T-cell regulation. LGALS3 has an important role in tumor progression through inhibition of apoptosis. LGALS3 expression is associated with neoplastic transformation and with differentiation of monocytes to macrophages. Elevated expression of LGALS3 has been demonstrated in the synovium of rheumatoid arthritis (RA). Diseases associated with LGALS3 include Follicular Adenoma and Papillary Carcinoma.

        Galectin 3/LGALS3 References

        • Dumic J, et al. (2006) Galectin-3: an open-ended story. Biochim Biophys Acta. 1760(4): 616-35.
        • Sharma UC, et al. (2004) Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation. 110(19): 3121-8.
        • Yan YP, et al. (2009) Galectin-3 mediates post-ischemic tissue remodeling. Brain Res. 1288: 116-24.

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