GABARAPL1 Proteins, cDNA Clones Research Reagents

All GABARAPL1 reagents are produced in house and quality controlled, including 19 GABARAPL1 Gene, 1 GABARAPL1 Protein, 1 GABARAPL1 qPCR. All GABARAPL1 reagents are ready to use.

GABARAPL1 Protein (1)

    GABARAPL1 cDNA Clone (19)

    NM_031412.2

    In cloning vector

    In lentiviral vector

    NM_001044294.1

    In cloning vector

    In lentiviral vector

    GABARAPL1 qPCR Primer (1)

    GABARAPL1 Background

    ATG8, also known as GABARAPL1, is a ubiquitin-like protein which has a crystal structure. ATG8 consists of a 5-stranded β-sheet, which is enclosed by two α-helices at one side and one α-helix at the other side and exhibits a conserved GABARAP domain. It functions in the formation of autophagosomal membranes. The transient conjugation of ATG8 to the autophagosomal membrane through a ubiquitin-like conjugation system is essential for autophagy in eukaryotes. Autophagy is induced upon nutrient depletion or rapamycin treatment and leads to the response of more than 3 autophagy-related (ATG) genes known so far, including ATG8.

    GABARAPL1 References

    • Ohsumi Y, et al. (2004) The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells. 9(7):611-8.
    • Geng J, et al. (2008) The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 9(9):859-644.
    • Suzuki NN, et al. (2005) The crystal structure of plant ATG12 and its biological implication in autophagy. Autophagy. 1(2):119-126.

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