Enterovirus 71 VP0 Proteins Research Reagents

All Enterovirus 71 VP0 reagents are produced in house and quality controlled, including 1 Enterovirus 71 VP0 Lysate, 1 Enterovirus 71 VP0 Protein. All Enterovirus 71 VP0 reagents are ready to use.

Enterovirus 71 VP0 Protein (1)

    Enterovirus 71 VP0 Lysate (1)

      Enterovirus 71 VP0 Background

      Human enterovirus 71 genome polyprotein is a member of the picornaviruses polyprotein family. It contains twopeptidase C3 domains, oneRdRp catalytic domain, oneSF3 helicase domain. Genome polyprotein is cleaved into the following 12 chains: Protein VP (VP4-VP2), Protein VP4 (P1A), Protein VP2 (P1B), Protein VP3 (P1C), Protein VP1 (P1D), Picornain 2A (P2A), Protein 2B (P2B), Protein 2C (P2C), Protein 3A (P3A), Protein 3B (P3B), Picornain 3C (Protease 3C) and RNA-directed RNA polymerase 3D-POL (P3D-POL). VP precursor is a component of immature procapsids. Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid composed of 6 copies of each VP1, VP2, and VP3, with a diameter of approximately 3 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes.

      Enterovirus 71 VP0 References

      • Brown B.A., et al., 1995, Virus Res. 39:195-206.
      • Tang W.-F. et al., 2007, J. Biol. Chem. 282:5888-5898.
      • Huang,S.C. et al., 2008, Virus Res. 131 (2):250-9.

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