Ephrin A5 Proteins, Antibodies, cDNA Clones Research Reagents

All Ephrin A5 reagents are produced in house and quality controlled, including 3 Ephrin A5 Antibody, 53 Ephrin A5 Gene, 9 Ephrin A5 Lysate, 9 Ephrin A5 Protein, 3 Ephrin A5 qPCR. All Ephrin A5 reagents are ready to use.

Ephrin A5 Protein (9)

    Ephrin A5 Antibody (3)

      Ephrin A5 cDNA Clone (53)


      In cloning vector


      Ephrin A5 Lysate (9)

        Ephrin A5 Background

        Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

        Ephrin A5 References

        • Frisén J, et al. (1998) Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20(2): 235-43.
        • Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.
        • Wahl S, et al. (2000) Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol. 149(2): 263-70.

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