Ephrin A5 Proteins, Antibodies, cDNA Clones Research Reagents

All Ephrin A5 reagents are produced in house and quality controlled, including 3 Ephrin A5 Antibody, 53 Ephrin A5 Gene, 9 Ephrin A5 Lysate, 9 Ephrin A5 Protein, 3 Ephrin A5 qPCR. All Ephrin A5 reagents are ready to use.

Ephrin A5 Protein (9)

    Ephrin A5 Antibody (3)

      Ephrin A5 cDNA Clone (53)

      NM_001962.2
      NM_207654.1
      NM_053903.1
      XM_001099753.2

      In cloning vector

      XM_845489.2

      Ephrin A5 Lysate (9)

        Ephrin A5 Background

        Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

        Ephrin A5 References

        • Frisén J, et al. (1998) Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20(2): 235-43.
        • Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.
        • Wahl S, et al. (2000) Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol. 149(2): 263-70.

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