EPCR Proteins, Antibodies, cDNA Clones Research Reagents

All EPCR reagents are produced in house and quality controlled, including 18 EPCR Antibody, 41 EPCR Gene, 7 EPCR Lysate, 7 EPCR Protein, 3 EPCR qPCR. All EPCR reagents are ready to use.

EPCR Protein (7)

    EPCR Antibody (18)

      EPCR cDNA Clone (41)

      BC014451
      NM_011171.2
      NM_001025733.2

      In cloning vector

      In lentiviral vector

      XM_001100647.2

      EPCR Lysate (7)

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        EPCR Background

        Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.

        EPCR References

        • Nicolaes GA, et al. (2003). Congenital and acquired activated protein C resistance. Semin Vasc Med. 3 (1): 33-46.
        • Esmon CT. ( 2003). The protein C pathway. Chest 124 (3): 26-32.
        • Mosnier LO, et al. (2007)The cytoprotective protein C pathway. Blood. 109: 3161-72.

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