EGFR Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All EGFR reagents are produced in house and quality controlled, including 30 EGFR Antibody, 2 EGFR ELISA, 52 EGFR Gene, 15 EGFR Lysate, 19 EGFR Protein, 3 EGFR qPCR. All EGFR reagents are ready to use.

EGFR Protein (19)

EGFR Antibody (30)

    EGFR ELISA Kit & Match Antibody ELISA Pair Set (2)

    EGFR cDNA Clone (52)

    NM_005228.3
    NM_207655.2
    HM801041.1
    XM_533073.3

    EGFR Lysate (15)

      EGFR Background

      As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

      EGFR References

      • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
      • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
      • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.

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