DR5/TRAIL R2 Proteins, Antibodies, cDNA Clones Research Reagents

TNFRSF10B (TNF Receptor Superfamily Member 10b) is a protein coding gene located on human chromosome 8p21.3. TNFRSF10B is also known as DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2 and KILLER/DR5. The human TNFRSF10B gene encodes a 47878 Da protein containing 440 amino acids. The TNFRSF10B protein is ubiquitously expressed in gall bladder, urinary bladder and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. TNFRSF10B is related to TRAIL binding. TNFRSF10A is an important paralog of TNFRSF10B gene. TNFRSF10B is associated with some diseases, including Squamous Cell Carcinoma, Head And Neck and Glioblastoma Multiforme.

DR5/TRAIL R2 Protein (6)

    DR5/TRAIL R2 Antibody (9)

      DR5/TRAIL R2 cDNA Clone (27)


      In cloning vector

      DR5/TRAIL R2 Lysate (5)

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        DR5/TRAIL R2 Background

        Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

        DR5/TRAIL R2 References

        • Schneider P, et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity. 7(6): 831-6.
        • Ichikawa K, et al. (2003) TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. J Immunol. 171(2): 1061-9.
        • Walczak H, et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-97.

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