DR3 Proteins, cDNA Clones Research Reagents

TNFRSF25 (TNF Receptor Superfamily Member 25) is a protein coding gene located on human chromosome 1p36.31. TNFRSF25 is also known as DR3, TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, GEF720, WSL-LR, PLEKHG5 and TNFRSF12. The human TNFRSF25 gene encodes a 45385 Da protein containing 417 amino acids. The TNFRSF25 protein is broadly expressed in skin, spleen and other tissues. Among its related pathways are Apoptosis Modulation and Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. TNFRSF25 is related to tumor necrosis factor-activated receptor activity. TNFRSF1A is an important paralog of TNFRSF25 gene. TNFRSF25 is associated with some diseases, including Autoimmune Disease Of Gastrointestinal Tract and Juvenile Dermatitis Herpetiformis.

DR3 Protein (2)

    DR3 cDNA Clone (13)


    DR3 qPCR Primer (1)

    DR3 Lysate (1)

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      DR3 Background

      Tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), also known as Death receptor 3 (DR3) or TNFRSF12 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. TNFRSF25/DR3/TNFRSF12 has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this TNFRSF25 encoding gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

      DR3 References

      • Slebioda TJ, et al. (2011) Triggering of TNFRSF25 promotes CD8? T-cell responses and anti-tumor immunity. Eur J Immunol. 41(9): 606-11.
      • Fang L, et al. (2008) Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J Exp Med. 205(5): 037-48.
      • Borysenko CW, et al. (2005) Comparative modeling of TNFRSF25 (DR3) predicts receptor destabilization by a mutation linked to rheumatoid arthritis. Biochem Biophys Res Commun. 328(3): 94-9.

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