Cytokeratin 5/KRT5 Antibodies, cDNA Clones Research Reagents

KRT5 (Keratin 5, also known as K5; CK5; DDD; DDD1; EBS2; KRT5A), located on 12q13.13, is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 62378 Da protein composed of 590 amino acids. The protein encoded by this gene is a member of the keratin gene family. Diseases such as Epidermolysis Bullosa Simplex With Mottled Pigmentation and Epidermolysis Bullosa Simplex, Generalized are associated with KRT5. The related pathways of KRT5 include Cytoskeleton remodeling Neurofilaments and Developmental Biology.

Cytokeratin 5/KRT5 Antibody (6)

    Cytokeratin 5/KRT5 cDNA Clone (45)

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    Cytokeratin 5/KRT5 Background

    Keratin 5 is the major type II keratin of the basal cells of the epidermis and other stratified epithelia. With its type I partner, keratin 14, it constitutes a major fraction of the cytoskeleton of the basal cells. Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP) is a rare dermatologic disorder of autosomal dominant inheritance with intraepidermal blistering after minor trauma, reticular hyperpigmentation unrelated to the blistering, nail dystrophy, and mild palmoplantar keratosis. Keratin 5 and keratin 14 are known to be essential for the basal keratinocyte cytoskeleton and are defective in several forms of epidermolysis bullosa simplex. Recently, a 71C-->T transition in the keratin 5 gene (KRT5) causing a P24L substitution was identified in some patients with EBS-MP.

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