CXCL7 Proteins, Antibodies, cDNA Clones Research Reagents

PPBP (Pro-Platelet Basic Protein) is a protein coding gene located on human chromosome 4q13.3. PPBP is also known as PBP, TC1, TC2, TGB, LDGF, MDGF, TGB1, B-TG1, CTAP3, CXCL7, NAP-2, SCYB7, THBGB, LA-PF4, THBGB1, Beta-TG, CTAPIII and CTAP-III. The human PPBP gene encodes a 13894 Da protein containing 128 amino acids. The PPBP protein is biasedly expressed in bone marrow, spleen and other tissues. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. PPBP is related to growth factor activity and glucose transmembrane transporter activity. CXCL1 is an important paralog of PPBP gene. PPBP is associated with some diseases, including Erythromelalgia and Essential Thrombocythemia.

CXCL7 Antibody (5)

    CXCL7 cDNA Clone (52)


    CXCL7 Lysate (2)

      More Product Popular With Customers

      CXCL7 Background

      Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

      CXCL7 References

      • Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
      • Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
      • Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.