Cx3cr1 Antibodies, cDNA Clones Research Reagents

CX3CR1 (C-X3-C Motif Chemokine Receptor 1) is a protein coding gene located on human chromosome 3p22.2. CX3CR1 is also known as V28, CCRL1, GPR13, CMKDR1, GPRV28 and CMKBRL1. The human CX3CR1 gene encodes a 40396 Da protein containing 355 amino acids. The CX3CR1 protein is biasedly expressed in brain, lung and other tissues. Among its related pathways are Signaling by GPCR and Akt Signaling. CX3CR1 is related to G protein-coupled receptor activity and chemokine receptor activity. CCR4 is an important paralog of CX3CR1 gene. CX3CR1 is associated with some diseases, including Macular Degeneration, Age-Related, 12 and Human Immunodeficiency Virus Type 1.

Cx3cr1 Antibody (1)

    Cx3cr1 cDNA Clone (5)

    NM_001171174.1

    In expression vector

    In lentiviral vector

    NM_009987.3

    In expression vector

    In lentiviral vector

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    Cx3cr1 Background

    The CX3C chemokine axis consists of fractalkine (CX3CL1) and its receptor (CX3CR1); these are expressed by neurons and microglia respectively, and are known to modulate microglial activation. Neuronal Cx3cr1 may impact Alzheimer's disease-like pathology by modulating conformational state-dependent amyloid-beta-induced synaptotoxicity. Microglial cells participate in brain development and influence neuronal loss and synaptic maturation. Fractalkine is an important neuronal chemokine whose expression increases during development and that can influence microglia function via the fractalkine receptor, CX3CR1. Mice lacking Cx3cr1 show a variety of neuronal defects thought to be the result of deficient microglia function. Knockout of the microglial chemokine receptor Cx3cr1 to prevent neuron loss.

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