CST6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All CST6 reagents are produced in house and quality controlled, including 11 CST6 Antibody, 2 CST6 ELISA, 26 CST6 Gene, 2 CST6 Lysate, 2 CST6 Protein, 2 CST6 qPCR. All CST6 reagents are ready to use.

CST6 Protein (2)

    CST6 Antibody (11)

      CST6 ELISA Kit & Match Antibody ELISA Pair Set (2)

      CST6 cDNA Clone (26)

      NM_001323.2
      NM_028623.5

      CST6 Lysate (2)

        CST6 Background

        Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.

        CST6 References

        • Ritonja A., et al.,(1985), Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver. Biochem. Biophys. Res. Commun. 131:1187-1192.
        • Pennacchio L.A., et al., (1996), Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).Science 271:1731-1734.
        • Ghaemmaghami S., et al.,(2003), Global analysis of protein expression in yeast.Nature 425:737-741.

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