CSNK1G1 Proteins, Antibodies, cDNA Clones Research Reagents

All CSNK1G1 reagents are produced in house and quality controlled, including 1 CSNK1G1 Antibody, 15 CSNK1G1 Gene, 1 CSNK1G1 Lysate, 1 CSNK1G1 Protein, 1 CSNK1G1 qPCR. All CSNK1G1 reagents are ready to use.

CSNK1G1 Protein (1)

    CSNK1G1 Antibody (1)

      CSNK1G1 cDNA Clone (15)

      CSNK1G1 qPCR Primer (1)

      CSNK1G1 Lysate (1)

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        CSNK1G1 Background

        Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are serine / threonine-selective enzymes that function as regulators ofsignal transductionpathways in most eukaryotic cell types. Casein has been used as a substrate since the earliest days of research on protein phosphorylation. Casein kinase activity associated with the endoplasmic reticulum of mammary glands was first characterized in 1974 and its activity was shown to not depend on cyclic AMP. The CKI family of monomeric serine–threonine protein kinases is found in eukaryotic organisms from yeast to human. Mammals have seven family members: alpha, beta 1, gamma 1, gamma 2, gamma 3, delta, and epsilon. The family members have the highest homology in their kinase domains (53%–98% identical) and differ from most other protein kinases by the presence of the sequence S-I-N instead of A-P-E in kinase domain VIII. The CKI family members appear to have similar substrate specificity and substrate selection is thought to be regulated via subcellular localization and docking sites in specific substrates.

        CSNK1G1 References

        • E. Bingham. et al.,1974, Journal of Biological Chemistry. 249: 3647-51.
        • Wojciech S. et al., 2004,  Journal of Biological Chemistry.279: 13011-7.
        • L. Lum. et al., 2004, Science Volume 304, pages 1755-9.
        • R. Takada. et al., 2005, Genes Cells Volume 10: 919-28.
        • G. Davidson. et al., 2005, Nature Volume 438:  867-72.

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