Cripto Proteins, Antibodies, cDNA Clones Research Reagents

TDGF1 (Teratocarcinoma-Derived Growth Factor 1) is a protein coding gene located on human chromosome 3p21.31. TDGF1 is also known as CR, CR-1, CRGF and CRIPTO. The human TDGF1 gene encodes a 21169 Da protein containing 188 amino acids. The TDGF1 protein is biasedly expressed in spleen, kidney and other tissues. Among its related pathways are Signaling by NODAL and NF-KappaB Family Pathway. TDGF1 is related to signaling receptor binding and growth factor activity. CFC1B is an important paralog of TDGF1 gene. TDGF1 is associated with some diseases, including Microform Holoprosencephaly and Septopreoptic Holoprosencephaly.

Cripto Protein (4)

    Cripto Antibody (2)

      Cripto cDNA Clone (26)

      NM_003212.2
      XM_001056317.2

      Cripto qPCR Primer (2)

      Cripto Lysate (4)

        Cripto Background

        Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in Cripto/TDGF1 can cause autosomal visceral heterotaxy. Cripto/TDGF1 is involved in left-right asymmetric morphogenesis during organ development. Cripto signalling is essential for the conversion of a proximal–distal asymmetry into an orthogonal anterior–posterior axis. The mechanism of inhibitory effects of the Cripto includes both cancer cell apoptosis, activation of c-Jun-NH(2)-terminal kinase and p38 kinase signaling pathways and blocking of Akt phosphorylation. Thus, Cripto is a unique target, and Immunohistochemistry to Cripto could be of therapeutic value for human cancers.

        Cripto References

        • Calvanese L, et al. (2006) Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala. J Med Chem. 49 (24): 7054-62.
        • Lonardo E, et al. (2010) A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease. Stem Cells. 28 (8): 1326-37.
        • Chambery A, et al. (2009) Qualitative and quantitative proteomic profiling of cripto(-/-) embryonic stem cells by means of accurate mass LC-MS analysis. J Proteome Res. 8 (2): 1047-58.

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