CR1/CD35 Antibodies, cDNA Clones Research Reagents

CR1 (Complement C3b/C4b Receptor 1 (Knops Blood Group), also known as KN; C3BR; C4BR; CD35), located on 1q32.2, is a Protein Coding gene. This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. CR1 is a multi-modular membrane receptor composed of 30 homologous complement control protein modules organized in four different functional regions called long homologous repeats. Human CR1 plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells.

CR1/CD35 Antibody (2)

    CR1/CD35 cDNA Clone (1)

    NM_000573.3

    In expression vector

    CR1/CD35 Background

    Complement receptor type 1 (CR1) is a multi-modular membrane receptor composed of 30 homologous complement control protein modules (CCP) organized in four different functional regions called long homologous repeats (LHR A, B, C, and D). CR1 is a receptor for complement-opsonins C3b and C4b and specifically interacts through pairs of CCP modules located in LHR A, B, and C. Human CR1 plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Lower CR1 expression has been associated with susceptibility to systemic lupus erythematosus (SLE). In contrast, subjects displaying lower CR1 expression are protected against severe manifestations of falciparum malaria. The CR1 gene was shown to be involved in Alzheimer's disease (AD).

    CR1/CD35 References

    • Sandri TL, et al. (2018) Human complement receptor type 1 (cr1) protein levels and genetic variants in chronic chagas disease. Sci Rep 8 (1): 526.
    • Panda AK, et al. (2016) Cr1 exon variants are associated with lowered cr1 expression and increased susceptibility to sle in a plasmodium falciparum endemic population. Lupus Sci Med 3 (1): e000145.
    • Mahmoudi R, et al. (2018) Inherited and acquired decrease in complement receptor 1 (cr1) density on red blood cells associated with high levels of soluble cr1 in alzheimer's disease. Int J Mol Sci 19 (8): 2175.
    • Jacquet M, et al. (2018) C1q and mannose-binding lectin interact with cr1 in the same region on ccp24-25 modules. Front Immunol 9 453.

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