CNDP2 Proteins, Antibodies, cDNA Clones Research Reagents

All CNDP2 reagents are produced in house and quality controlled, including 5 CNDP2 Antibody, 30 CNDP2 Gene, 1 CNDP2 IP Kit, 2 CNDP2 Lysate, 2 CNDP2 Protein, 2 CNDP2 qPCR. All CNDP2 reagents are ready to use.

CNDP2 Protein (2)

    CNDP2 Antibody (5)

      CNDP2 cDNA Clone (30)

      CNDP2 Lysate (2)

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        CNDP2 Background

        Cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to thepeptidase M2A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Itmay be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.

        CNDP2 References

        • Bakker,SJ. et al., 2008, Diabetes  57 (12):e16; author reply e17. 
        • Wanic, K. et al., 2008, Diabetes  57 (9): 2547-51.
        • McDonough,CW. et al., 2009, Hum Genet 126 (2): 265-75.
        • Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.

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