Chemerin/RARRES2 Proteins, cDNA Clones Research Reagents

RARRES2 (Retinoic Acid Receptor Responder 2) is a protein coding gene located on human chromosome 7q36.1. RARRES2 is also known as TIG2 and HP10433. The human RARRES2 gene encodes a 18618 Da protein containing 163 amino acids. The RARRES2 protein is broadly expressed in adrenal, fat and other tissues. Among its related pathways are Response to elevated platelet cytosolic Ca2+. RARRES2 is related to signaling receptor binding. RARRES2 is associated with some diseases, including Monckeberg Arteriosclerosis and Skin Squamous Cell Carcinoma.

Chemerin/RARRES2 Protein (2)

    Chemerin/RARRES2 cDNA Clone (26)


    Chemerin/RARRES2 Lysate (2)

      Chemerin/RARRES2 Background

      Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Previous studies suggested that it can serve as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumor. Mechanistically, RARRES2 overexpression in ACC cells inhibited Wnt/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase. Thus RARRES2 is a novel tumor suppressor for ACC, which can function through an immune-independent mechanism.

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