CD8 beta Proteins, Antibodies, cDNA Clones Research Reagents

All CD8 beta reagents are produced in house and quality controlled, including 4 CD8 beta Antibody, 40 CD8 beta Gene, 2 CD8 beta Lysate, 3 CD8 beta Protein, 2 CD8 beta qPCR. All CD8 beta reagents are ready to use.

CD8 beta Protein (3)

    CD8 beta Antibody (4)

      CD8 beta cDNA Clone (40)

      NM_172099.2
      NM_009858.2
      XM_005575357.2

      In expression vector

      XR_010580.2

      CD8 beta Lysate (2)

        CD8 beta Background

        CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. P37 gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. CD8 is thought to play a role in the process of T-cell mediated killing.

        CD8 beta References

        • Leahy DJ, et al. (1992) Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell. 68(6):1145-62.
        • Gao G, et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol Today. 21(12):630-6.
        • Devine L, et al. (1999) Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J Immunol. 162(2):846-51.

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