CD30/TNFRSF8 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

TNFRSF8 (TNF Receptor Superfamily Member 8) is a protein coding gene located on human chromosome 1p36.22. TNFRSF8 is also known as CD30, Ki-1 and D1S166E. The human TNFRSF8 gene encodes a 63747 Da protein containing 595 amino acids. The TNFRSF8 protein is broadly expressed in appendix, fat and other tissues. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling. TNFRSF8 is related to transmembrane signaling receptor activity. TNFRSF1B is an important paralog of TNFRSF8 gene. TNFRSF8 is associated with some diseases, including Peripheral T-Cell Lymphoma and Reticulosarcoma.

CD30/TNFRSF8 Protein (8)

    CD30/TNFRSF8 Antibody (16)

      CD30/TNFRSF8 ELISA Kit & Match Antibody ELISA Pair Set (2)

      CD30/TNFRSF8 cDNA Clone (16)

      NM_001243.3
      NM_009401.2

      In cloning vector

      In lentiviral vector

      XM_015442579.1

      In expression vector

      CD30/TNFRSF8 qPCR Primer (1)

      CD30/TNFRSF8 Lysate (6)

        CD30/TNFRSF8 Background

        CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

        CD30/TNFRSF8 References

        • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
        • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
        • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
        • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
        • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
        • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.

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