CD103 Antibodies, cDNA Clones Research Reagents

ITGAE (Integrin Subunit Alpha E, also known as CD103; HUMINAE), located on 17p13.2, is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The gene produces a 130159 Da protein composed of 1179 amino acids. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Diseases such as Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma are associated with ITGAE. The related pathways of ITGAE include the Integrin Pathway and Degradation of the extracellular matrix.

CD103 Antibody (1)

    CD103 cDNA Clone (2)

    NM_008399.1

    In lentiviral vector

    In expression vector

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    CD103 Background

    ITGAE (Integrin Subunit Alpha E) is a Protein Coding gene. Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. ITGAE belongs to the integrin alpha chain family. Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. The integrin alpha(E)beta(7) is believed to play a key role in the retention of lymphocytes in mucosal tissues of the gut, urogenital tract, and lung. ITGAE(+) cells play a key role in the development of autoimmune diabetes and are consistent with the hypothesis that ITGAE(+)CD8(+)T effectors initiate the disease process. Diseases associated with ITGAE include Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma.

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