ITGAE (Integrin Subunit Alpha E) is a Protein Coding gene. Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. ITGAE belongs to the integrin alpha chain family. Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. The integrin alpha(E)beta(7) is believed to play a key role in the retention of lymphocytes in mucosal tissues of the gut, urogenital tract, and lung. ITGAE(+) cells play a key role in the development of autoimmune diabetes and are consistent with the hypothesis that ITGAE(+)CD8(+)T effectors initiate the disease process. Diseases associated with ITGAE include Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma.