Carbonic Anhydrase VB Proteins, Antibodies, cDNA Clones Research Reagents

All Carbonic Anhydrase VB reagents are produced in house and quality controlled, including 5 Carbonic Anhydrase VB Antibody, 15 Carbonic Anhydrase VB Gene, 1 Carbonic Anhydrase VB IP Kit, 1 Carbonic Anhydrase VB Protein, 1 Carbonic Anhydrase VB qPCR. All Carbonic Anhydrase VB reagents are ready to use.

Carbonic Anhydrase VB Protein (1)

    Carbonic Anhydrase VB Antibody (5)

      Carbonic Anhydrase VB cDNA Clone (15)

      Carbonic Anhydrase VB qPCR Primer (1)

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      Carbonic Anhydrase VB Background

      Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CAs show extensive diversity in tissue distribution and in their subcellular localization. CA5B / CA-VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA5A / CA-VA. CA5B / CA-VB has a wider tissue distribution than CA5A / CA-VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. CA5A / CA-VA is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. It is inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt). CA5B / CA-VB is inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).

      Carbonic Anhydrase VB References

      • Fujikawa-Adachi K, et al.,1999, J Biol Chem. 274 (30): 21228-33.
      • Liao, S.Y. et al., 2003, J. Med. Genet. 40:257 - 262.
      • Temperini al., 2006, Chemistry 12: 7057-66.
      • Temperini al., 2006, J. Med. Chem. 49: 3019-27.
      • Supuran, C. T. et al., 2008, Curr Pharm Des. 14 (7): 601-602.
      • Elleuche, S. et al., 2009, Curr Genet. 55 (2): 211-222.
      • Maresca, al., 2009, J. Am. Chem. Soc. 131:3057-3062.

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