Calcineurin B/PPP3R1 Proteins, Antibodies, cDNA Clones Research Reagents

PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B, Alpha) is a protein coding gene located on human chromosome 2p14. PPP3R1 is also known as CNB, CNB1 and CALNB1. The human PPP3R1 gene encodes a 19300 Da protein containing 170 amino acids. The PPP3R1 protein is ubiquitously expressed in brain, fat and other tissues. Among its related pathways are Nur77 Signaling in T-Cell and Signaling by GPCR. PPP3R1 is related to calcium ion binding and calmodulin binding. ENSG00000273398 is an important paralog of PPP3R1 gene. PPP3R1 is associated with some diseases, including Gallbladder Small Cell Carcinoma and Deafness, Autosomal Dominant 58.

Calcineurin B/PPP3R1 Protein (1)

    Calcineurin B/PPP3R1 Antibody (1)

      Calcineurin B/PPP3R1 cDNA Clone (18)

      NM_024459.2

      In expression vector

      NM_017309.2

      In cloning vector

      In lentiviral vector

      Calcineurin B/PPP3R1 qPCR Primer (1)

      Calcineurin B/PPP3R1 Lysate (1)

        Calcineurin B/PPP3R1 Background

        PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. PPP3R1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase which takes a vital part in the T cell activation pathway. PPP3R1 is involved in protein dephosphorylation, NFAT protein import into nucleus (ortholog) and epithelial to mesenchymal transition (ortholog). It participates in calcineurin signaling pathway; mitogen activated protein kinase signaling pathway. PPP3R1 interacts with (+)-pilocarpine, 2,4-dinitrotoluene and ammonium chloride. It contains four EF-hand domains and four functional calcium-binding sites. PPP3R1 plays an important role in the T cell activation pathway.

        Calcineurin B/PPP3R1 References

        • Feng B, et al. (1999) Interactions of calcineurin A, calcineurin B, and Ca2+. Biochemistry 38 (38): 12481-9.
        • Kawamura A, et al. (1995) Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain. J Biol Chem. 270(26):15463-6.
        • Wang MG, et al. (1997) Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21q22 and 2p16p15 respectively. Cytogenet Cell Genet. 72(2-3):236-41.

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