Calcineurin A/PPP3CA Proteins, Antibodies, cDNA Clones Research Reagents

PPP3CA (Protein Phosphatase 3 Catalytic Subunit Alpha) is a protein coding gene located on human chromosome 4q24. PPP3CA is also known as CALN, CCN1, CNA1, CALNA, IECEE, PPP2B, ACCIID, CALNA1 and IECEE1. The human PPP3CA gene encodes a 58688 Da protein containing 521 amino acids. The PPP3CA protein is broadly expressed in brain, prostate and other tissues. Among its related pathways are Nur77 Signaling in T-Cell and B cell receptor signaling pathway (KEGG). PPP3CA is related to calcium ion binding and enzyme binding. PPP3CB is an important paralog of PPP3CA gene. PPP3CA is associated with some diseases, including Arthrogryposis, Cleft Palate, Craniosynostosis, And Impaired Intellectual Development and Epileptic Encephalopathy, Infantile Or Early Childhood, 1.

Calcineurin A/PPP3CA Protein (1)

    Calcineurin A/PPP3CA Antibody (1)

      Calcineurin A/PPP3CA cDNA Clone (32)

      XM_006233363.2

      In cloning vector

      In lentiviral vector

      Calcineurin A/PPP3CA qPCR Primer (1)

      Calcineurin A/PPP3CA Lysate (1)

        Calcineurin A/PPP3CA Background

        PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of the immune system and can be blocked by drugs. It also activates NFATc (a transcription factor) by dephosphorylating it. The activated NFATc is subsequently translocated into the nucleus, where it upregulates the expression of interleukin 2. PPP3CA interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. It also interacts with DNM1L. The interaction dephosphorylates DNM1L and regulates its translocation to mitochondria.

        Calcineurin A/PPP3CA References

        • Frey N, et al. (2002) Calsarcin-3, a Novel Skeletal Muscle-specific Member of the Calsarcin Family, Interacts with Multiple Z-disc Proteins. Journal of Biological Chemistry. 277(16): 13998-4004.
        • Frey N, et al. (2000) Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proceedings of the National Academy of Sciences. 97(26):14632-7.
        • Crabtree G R, et al. (1999) Generic signals and specific outcomes: Signaling through Ca2+, calcineurin, and NF-AT. Cell. 96(5):611-4.

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