BRG1 Antibodies, cDNA Clones Research Reagents

SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4), a member of the SWI/SNF family of proteins, is a protein coding gene located on human chromosome 19p13.2. SMARCA4 is also known as BRG1, CSS4, SNF2, SWI2, hSNF2b, BAF190A and SNF2-beta. The SMARCA4 protein is ubiquitously expressed in testis, brain and other tissues. The SMARCA4 gene encodes a catalytic subunit of SWI/SNF complexes, which function as regulators of gene expression. SMARCA4 is related to chromatin binding and transcription coactivator activity. SMARCA4 is associated with some diseases, including Coffin-Siris Syndrome 4 and Rhabdoid Tumor Predisposition Syndrome 2.

BRG1 Antibody (1)

    BRG1 cDNA Clone (2)


    In expression vector

    BRG1 Background

    The gene encoding the ATPase of the chromatin remodeling SWI/SNF complexes SMARCA4 (BRG1) is often mutated or silenced in tumors, suggesting a role as tumor suppressor. A high expression of SMARCA4 is associated with aggressive tumors, a high expression of SMARCA2 is associated with benign differentiated tumors, suggesting that SMARCA4 and SMARCA2 play opposite roles in cancer. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. The absence of SMARCA4/BRG1 immunostaining proved very useful in the diagnosis of hypercalcemic small cell ovarian carcinoma.

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