BLNK Proteins, Antibodies, cDNA Clones Research Reagents

All BLNK reagents are produced in house and quality controlled, including 3 BLNK Antibody, 15 BLNK Gene, 1 BLNK Lysate, 1 BLNK Protein. All BLNK reagents are ready to use.

BLNK Protein (1)

    BLNK Antibody (3)

      BLNK cDNA Clone (15)


      In expression vector

      BLNK Lysate (1)

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        BLNK Background

        B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains oneSH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon. BLNK functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. BLNK plays a role in the activation of ERK / EPHB2, MAP kinase p38 and JNK. BLNK modulates AP1 activation. It is important for the activation of NF-kappa-B and NFAT. BLNK plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+mobilization and is required for trafficking of the BCR to late endosomes. BLNK may be required for the RAC1-JNK pathway. It plays a critical role in orchestrating the pro-B cell to pre-B cell transition. BLNK also plays an important role in BCR-induced B-cell apoptosis.Defects in BLNK are the cause of agammaglobulinemia type 4 (AGM4) which is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

        BLNK References

        • Fu C., et al., 1998, Immunity 9:93-103.
        • Minegishi Y., et al., 1999, Science 286:1954-1957.
        • Chiu C.W., et al., 2002, EMBO J. 21:6461-6472.
        • Taguchi T., et al., 2004, Immunology 112:575-582.

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