Biglycan Proteins, Antibodies, cDNA Clones Research Reagents

All Biglycan reagents are produced in house and quality controlled, including 1 Biglycan Antibody, 26 Biglycan Gene, 2 Biglycan Lysate, 2 Biglycan Protein, 2 Biglycan qPCR. All Biglycan reagents are ready to use.

Biglycan Protein (2)

    Biglycan Antibody (1)

      Biglycan cDNA Clone (26)

      NM_001711.3
      NM_007542.4

      Biglycan Lysate (2)

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        Biglycan Background

        Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity.

        Biglycan References

        • Fisher L.W., et al.,(1989), Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J. Biol. Chem. 264:4571-4576.
        • Fisher L.W., et al., (1991), Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization.J. Biol. Chem. 266:14371-14377.
        • Mallon A.-M., et al.,(2000), Comparative genome sequence analysis of the Bpa/Str region in mouse and man.Genome Res. 10:758-775.

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