B7-H4 Proteins, Antibodies, cDNA Clones Research Reagents

VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) is a protein coding gene located on human chromosome 1p13.1-p12. VTCN1 is also known as B7X, B7H4, B7S1, B7-H4, B7h.5, VCTN1 and PRO1291. The human VTCN1 gene encodes a 30878 Da protein containing 282 amino acids. The VTCN1 protein is biasedly expressed in kidney, pancreas and other tissues. Among its related pathways are Cell adhesion molecules (CAMs) and NF-kappaB Signaling. VTCN1 is related to signaling receptor binding. CD276 is an important paralog of VTCN1 gene. VTCN1 is associated with some diseases, including Lung Cancer and Ovarian Cancer.

B7-H4 Protein (11)

B7-H4 Antibody (3)

    B7-H4 cDNA Clone (28)


    In cloning vector


    In expression vector

    B7-H4 Lysate (7)

      B7-H4 Background

      V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.

      B7-H4 References

      • Zang X, et al. (2003) B7x: a widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci U S A. 100(18): 10388-92.
      • Suh WK, et al. (2006) Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol. 26(17): 6403-11.
      • Zang X, et al. (2007) B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A. 104(49):19458-63.

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