B7-1 Proteins, Antibodies, cDNA Clones Research Reagents

All B7-1 reagents are produced in house and quality controlled, including 22 B7-1 Antibody, 52 B7-1 Gene, 10 B7-1 Lysate, 13 B7-1 Protein, 3 B7-1 qPCR. All B7-1 reagents are ready to use.

B7-1 Protein (13)

    B7-1 Antibody (22)

      B7-1 cDNA Clone (52)


      B7-1 Lysate (10)

        B7-1 Background

        The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

        B7-1 References

        • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
        • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
        • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.

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