ARMET/MANF Proteins, Antibodies, cDNA Clones Research Reagents

MANF (Mesencephalic Astrocyte Derived Neurotrophic Factor, also known as ARP; ARMET), located on 3p21.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, zebrafish, fruit fly, mosquito, C.elegans, and frog. The gene produces a 20700 Da protein composed of 182 amino acids. The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and Golgi. MANF is a secreted protein that belongs to the ARMET family. It has been described as a survival factor for dopaminergic neurons. The related pathways of MANF include Response to elevated platelet cytosolic Ca2+.

ARMET/MANF Protein (3)

    ARMET/MANF Antibody (5)

      ARMET/MANF cDNA Clone (28)


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      In lentiviral vector

      ARMET/MANF Lysate (3)

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        ARMET/MANF Background

        Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral midbrain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus, and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggests that it has important functions both under normal and pathological conditions in many tissue types.

        ARMET/MANF References

        • Shridhar V., et al., 1996, Oncogene 12:1931-1939.
        • Gevaert K., et al., 2003, Nat. Biotechnol. 21:566-569.
        • Petrova P., et al., 2003, J. Mol. Neurosci. 20:173-188.
        • Lindholm, P. et al., 2008, Mol Cell Neurosci. 39 (3):356-71.
        • Airavaara, M. et al., 2010, Exp Neurol. 225 (1):104-13.

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