ALK4/ACVR1B Proteins, Antibodies, cDNA Clones Research Reagents

All ALK4/ACVR1B reagents are produced in house and quality controlled, including 2 ALK4/ACVR1B Antibody, 65 ALK4/ACVR1B Gene, 6 ALK4/ACVR1B Lysate, 6 ALK4/ACVR1B Protein, 2 ALK4/ACVR1B qPCR. All ALK4/ACVR1B reagents are ready to use.

ALK4/ACVR1B Protein (6)

    ALK4/ACVR1B Antibody (2)

      ALK4/ACVR1B cDNA Clone (65)

      NM_004302.3
      NM_007395.3
      NM_199230.1
      XM_543663.3
      XM_001091363.2

      ALK4/ACVR1B Lysate (6)

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        ALK4/ACVR1B Background

        ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

        ALK4/ACVR1B References

        • Chen Y, et al. (2005) Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. 232(2): 393-8.
        • J. Massagu. (1998) TGF- SIGNAL TRANSDUCTION. Annual Review of Biochemistry. 67: 753-91.

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