IL-15:Greatest Potential Use in Tumor Immunotherapy

Inrerleukin-15 (IL-15), a pluripotent cytokine with pleiotropic functions in innate and adaptive immunity, belongs to the 4α-helix bundle family which is featured as a common gamma-chain (γc) shared by their receptors. IL-15 is widely produced in many cells, and acts as regulator of immune response, especially in induction and maintenance of T cell response. The multifaceted activity makes IL-15 the most potential candidate in tumor immunotherapy.

IL-15 Antitumor Activity CD8+ T
Cell
CD4+ T
Cell
Memory CD8+
T Cell
Dendritic
Cell
NK
Cell
NKT
Cell
B Cell Killer
DCs
Activation                
Proliferation                
Differentiation                
Survival                
More Activity Protect from Treg cell   Immunizing Potent Priming   Ig Production • IFN-γ Production
• Cytotoxicity

IL-15 has a high affinity to the receptor subunit IL-15Rα, which is different from IL-2 to IL-2Rα. Effector IL-15 is secreted as a IL-15/IL-15Rα complex form instead of solube IL-15, and IL-15Rα can prolong its half-life to some extent. Downstream signal will be actived by the following binding to IL-2/15Rβ (identical with IL-2Rβ) and γc chain (shared with other 4α-helix bundle family members, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21). What’s more, IL-15 alone does not form a stable complex with IL-2/15 Rβ and γc.

Sino Biological has developed high bio-activity IL-15 proteins and IL-15 receptor to help research the biology of IL-15.

High Bio-activity Recombinant IL-15

Cell proliferation assay has been taked by using MO7e human megakaryocytic leukemic cells.

Human IL-15, His Tag
10360-H07E
Human IL-15, N-cleavage
10360-HNCE

Recombinant IL-15 Receptor

Human IL15Rα Protein (ECD, Fc Tag)
18366-H02H1

Recombinant IL15 & IL15Rα

Human IL15Rα & IL-15 (N120D) Heterodimer Protein (Fc Tag)
CT094-H02H