In 1985, two distinct forms of IL-1, IL-1α and IL-1β, were reported to be isolated from a macrophage cDNA library. Since then, the IL-1 family has continued to expand so that it has 11 members now. Unlike other cytokine family, the Interleukin-1 (IL-1) family primarily plays important roles in innate immunity, activating and regulating inflammation in response to injury or infection.
Based on the length of the N-term pro-pieces, the members of IL-1 family can be classified into 3 subfamilies: IL-1 subfamily (IL-1α, IL-1β and IL-33, IL-1Ra), IL-18 subfamily (IL-18 and IL-37), and IL-36 subfamily (IL-36α, IL-36β, IL-36γ, and IL-38).
|IL-1 subfamily||IL-1α||IL-1R1, IL-1R2||IL-1RAcP|
: Pro-inflammatory cytokine; : Anti-inflammatory cytokine.
IL-1 family cytokines bind to their cognate cell surface receptors and initiate signaling. IL-1, IL-33 and IL-36 bind specific receptors, IL-1R1, ST2, and IL-1Rrp2 respectively. They use IL1RAcP as a co-receptor. The formed complexes trigger intracellular signaling cascades. IL-1 family signal transduction is an important part of the inflammatory response, and ultimately helps to coordinate innate and adaptive immunity to fight against a variety of pathogens. However, abnormal signaling in these systems can lead to autoinflammatory diseases, autoimmune diseases and cancers. Scientists are working together to solve these problems and several inhibitors of IL-1 signaling have been clinically approved, such as Anakinra (recombinant IL-1Ra), Gevokizumab (anti-IL-1β mAb).
To accelerate your inflammation and signaling research, Sino Biological provides a large panel of IL-1 family related reagents, covering recombinant proteins, antibodies and ELISA Kits.
Sino Biological has developed bioactive recombinant proteins for cell based assays. These proteins cover various species, such as human, mouse, rabbit and Sus scrofa (Pig).
Binds Human IL1R2 Protein,
Fc Tag (Cat#: 10111-H02H), KD=6.0 nM.
|His Tag (Pro Form)
|GST Tag (Pro Form)
|50073-MNCE||His Tag (Pro Form)
|His & Fc Tag
|His Tag (Mature Form)
|Mature Isoform 2
Note: H: Human; R: Rat; Ra: Rabbit; P: Sus scrofa (Pig); M: Mouse; C: Canine; Rh: Rhesus; Cy: Cynomolgus.
Sandwich ELISA is a common technique to detect and quantify IL-1 family cytokines in samples. For your IL-1 family cytokine research, Sino Biological offers two different ELISA detection products: ELISA Kits and Matched ELISA Antibody Pairs.
ELISA Kits are ready-to-use immunoassay kits that contain all the reagents needed to perform an ELISA, including a 96-well microplate coated with capture antibody, detection antibody, standard, buffers and color reagents.
Matched ELISA Antibody Pairs are cost-effective alternatives to ELISA Kits. Each set of our Matched ELISA Antibody Pairs is fully validated and contains a recombinant protein standard, capture antibody and detection antibody.