CD155 and its Receptors

Potential Immuno-oncology Targets

CD155, also known as poliovirus receptor (PVR), is involved in many different processes such as cell adhesion, migration and proliferation. CD155 is a shared ligand for the costimulatory receptor DNAM-1 (CD226) and the coinhibitory receptors TIGIT and CD96. CD155 interacts with these receptors to mediate immune cell activation or inhibition. However, these functions are usually changed in the tumor microenvironment, thereby contributing to tumor immunosuppression. Thus, targeting CD155-mediated immune regulation via interaction with these receptors is very promising in the field of anti-tumor therapy.

Sino Biological provides a wide panel of research reagents for studying the interactions between CD155 and its receptors (DNAM-1, TIGIT, CD96), as well as the immunoregulatory effects related to these receptors.

Bioactive Recombinant CD155 with Validated Activity

Cat# Species Activity Validated
10109-H02H-B Human Binds human CD226-His (Cat#: 10565-H08H)
10109-H08H Human Binds human CD226 (Cat#: 10565-H03H)
50259-M38H Mouse Binds mouse TIGIT-His (Cat#: HPLC-50939-M08H)
HPLC-50259-M08H Mouse Binds mouse TIGIT,  mFc tag (Cat#: 50939-M38H)
50259-M41H-B Rat Binds mouse CD226
90005-C08H Rhesus Binds human CD226
Human CD155, Fc tag (Cat#: 10109-H02H)
10109-H02H
Binds human CD226-His protein (Cat#: 10565-H08H)

Biotinylated human CD155, His tag (Cat#: 10109-H08H-B) and mouse CD155 (Cat#: 50259-M41H-B) are also available for your research use.

CD155 Antibodies for FACS Screening

Sino Biological offers anti-human and mouse CD155 monoclonal antibodies for flow cytometry. These antibodies are conjugated to different conjugates, including APC, FITC, PE and PerCP.

If the labeled version you need is not available, you can select unconjugated CD155 antibodies and label them by yourself.

Note: H: Human; M: Mouse.

Bioactive Recombinant CD155 Receptors

Recombinant CD155 receptors are HEK293 expressed and have binding activity to CD155 in ELISA. For each CD155 receptor, Sino Biological offfers recombinant proteins from various species.

Partial List of Recombinant CD155 Receptors

Protein Cat# Species Tag Activity
CD226 10565-H08H-B Human Fc Tag  
50232-M03H Mouse His & Fc Tag binding activity
80369-R08H Rat His Tag binding activity
TIGIT 10917-H02H-B Human Fc Tag binding activity
50939-M08H Mouse His Tag binding activity
8A6318-R02H Rat Fc Tag  
90890-C02H Cynomolgus Fc Tag binding activity
CD96 11202-H08H-B Human His Tag binding activity
50758-M08H Mouse His Tag binding activity

Anti-CD155 Receptors Antibodies

Our antibodies are validated for applications, such as ELISA, flow cytometry, and western blotting. Both unconjugated and fluorochrome-labeled antibodies are available.

  • Cat#: 50232-R026-F
    Specificity: Mouse CD226
    Type: Rabbit MAb
    Application: FCM
    Conjugate: FITC
    Purification: Protein A
  • Cat#: 50939-T24
    Specificity: Mouse TIGIT
    Type: Rabbit PAb
    Application: ELISA, IHC-P
    Conjugate: No
    Purification: Protein A & Antigen Affinity
  • Cat#: 50232-R026-A
    Specificity: Mouse CD226
    Type: Rabbit MAb
    Application: FCM
    Conjugate: APC
    Purification: Protein A
  • Cat#: 50758-T48
    Specificity: Mouse CD96
    Type: Rabbit PAb
    Application: WB, ELISA
    Conjugate: No
    Purification: Protein A & Antigen Affinity

Partial List of Anti-CD155 Receptors Antibodies

  • Anti-CD226
    50232-R026
    Rabbit MAb
    Rabbit IgG Clone #26
    ELISA, FCM
  • Anti-TIGIT
    10917-MM52
    Mouse MAb
    Mouse IgG1 Clone #52
    ELISA
  • Anti-CD96
    11202-RP01
    Rabbit PAb
    Rabbit IgG
    ELISA
  • Anti-CD226
    50232-R026-P
    Rabbit MAb
    Rabbit IgG Clone #26
    FCM
  • Anti-TIGIT
    50939-RP01
    Rabbit PAb
    Rabbit IgG
    ELISA
  • Anti-CD96
    50758-T16
    Rabbit PAb
    Rabbit IgG
    ELISA

Note: H: Human; M: Mouse.