Aconitase 1/ACO1 Proteins, cDNA Clones Research Reagents

All Aconitase 1/ACO1 reagents are produced in house and quality controlled, including 15 Aconitase 1/ACO1 Gene, 1 Aconitase 1/ACO1 Lysate, 1 Aconitase 1/ACO1 Protein, 1 Aconitase 1/ACO1 qPCR. All Aconitase 1/ACO1 reagents are ready to use.

Aconitase 1/ACO1 Protein (1)

    Aconitase 1/ACO1 cDNA Clone (15)

    Aconitase 1/ACO1 qPCR Primer (1)

    Aconitase 1/ACO1 Lysate (1)

      Aconitase 1/ACO1 Background

      Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 can assume two different functions in cells, depending on different conditions. During iron scarcity or oxidative stress, ACO1 binds to mRNA stem-loop structures called iron responsive elements to modulate the translation of iron metabolism genes. In iron-rich conditions, ACO1 binds an iron-sulfur cluster to function as a cytosolic aconitase.

      Aconitase 1/ACO1 References

      • Robbins AH, et al. (1989) The structure of aconitase. Proteins: Structure, Function, and Bioinformatics. 5 (4): 289-312.
      • Volz K. (2008) The functional duality of iron regulatory protein 1. Curr Opin Struct Biol. 18 (1): 106-11.
      • Gruer MJ, et al. (1997) The aconitase family: three structural variations on a common theme. Trends Biochem Sci. 22 (1): 3-6.

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