14-3-3 sigma Proteins, Antibodies, cDNA Clones Research Reagents

SFN (Stratifin) is a protein coding gene located on human chromosome 1p36.11. SFN is also known as YWHAS. The human SFN gene encodes a 27774 Da protein containing 248 amino acids. Among its related pathways are Apoptosis Modulation and Signaling and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. SFN is related to protein kinase binding and phosphoprotein binding. YWHAZ is an important paralog of SFN gene. SFN is associated with some diseases, including Benign Breast Adenomyoepithelioma and Fetal Encasement Syndrome.

14-3-3 sigma Protein (3)

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      14-3-3 sigma Background

      14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathways. More than 1 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

      14-3-3 sigma References

      • Zakut-Houri R., et al.,(1985), Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4:1251-1255.
      • Lamb P., et al., (1986), Characterization of the human p53 gene.Mol. Cell. Biol. 6:1379-1385.
      • Harlow E., et al.,(1985), Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.Mol. Cell. Biol. 5:1601-1610.

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