Cadherin 17 / CDH17: Cadherin 17 / CDH17 Protein | Cadherin 17 / CDH17 Antibody

Cadherin 17 / CDH17 Gene family

Cadherin 17 / CDH17 Background

Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.

Reference for Cadherin 17 / CDH17

  • Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63.
  • Ito R, et al. (2005) Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. Virchows Arch. 447(4): 717-22.
  • Horsfield J, et al. (2002) Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mech Dev. 115(1-2): 15-26.

Cadherin 17 / CDH17 Protein

Cadherin 17 / CDH17 protein function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269|PubMed:8153632}.

Cadherin 17 / CDH17 protein expression

Tissue specificity

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.

Cadherin 17 / CDH17 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    832.00
  • Mass (Da)
    92.00

Cadherin 17 / CDH17 Antibody

There are 8 Cadherin 17 / CDH17 antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, WB, IP. There are 4 Cadherin 17 / CDH17 antibody for IHC-P, 5 Cadherin 17 / CDH17 antibody for ELISA, 1 Cadherin 17 / CDH17 antibody for WB, 1 Cadherin 17 / CDH17 antibody for IP. Among all these Cadherin 17 / CDH17 antibodies, there are 4 anti-Cadherin 17 / CDH17 rabbit polyclonal antibodies , 2 anti-Cadherin 17 / CDH17 mouse monoclonal antibodies , 2 anti-Cadherin 17 / CDH17 rabbit monoclonal antibodies . All the Cadherin 17 / CDH17 anbodies are produced in house and all are in stock. Cadherin 17 / CDH17 antibody customerized service is available.

Cadherin 17 / CDH17 Gene

CDH17 gene / cDNA is a protein-coding gene which located on 8q22.1. The CDH17 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.234 organisms have orthologs with human gene CDH17.