BDNF: BDNF Protein | BDNF Antibody

BDNF Gene family

BDNF Background

BDNF is a member of the <a href="/NGF-NGFB-Protein-Antibody-a-222.html">nerve growth factor</a> family. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Reference for BDNF

  • Zigova T, et al. (1998) Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci. 11(4):234-45.
  • Acheson A, et al. (1995) A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374(6521):450-3.
  • Bekinschtein P, et al. (2008) BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci. 105(7):2711-6.

BDNF Protein

BDNF protein function

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269|PubMed:12553913}.

BDNF protein expression

Tissue specificity

Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

BDNF protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    247.00
  • Mass (Da)
    27.00

BDNF Antibody

There are 3 BDNF antibodies which are validated in multiple tissues with various applications, including WB, ELISA. There are 2 BDNF antibody for WB, 3 BDNF antibody for ELISA. Among all these BDNF antibodies, there are 1 anti-BDNF rabbit monoclonal antibodies , 2 anti-BDNF rabbit polyclonal antibodies . All the BDNF anbodies are produced in house and all are in stock. BDNF antibody customerized service is available.

BDNF Gene

BDNF gene / cDNA is a protein-coding gene which located on 11p14.1. The BDNF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.239 organisms have orthologs with human gene BDNF.