Anti-Olig2 Antibody, Rabbit Polyclonal
Cat: 100137-RP02
Anti-Olig2 Antibody, Rabbit Polyclonal General Information
Product name
Anti-Olig2 Antibody, Rabbit Polyclonal
Validated applications
WB,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human Olig2
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human Olig-2.
Preparation
Produced in rabbits immunized with purified, a synthetic peptide corresponding to the N-terminus of the Human Olig-2 / Oligo2, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-Olig2 Antibody, Rabbit Polyclonal Validated Applications
| Application | Dilution |
|---|---|
| WB | 1:500-1:2000 |
| IHC-P | 1:500-1:2000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-Olig2 Antibody, Rabbit Polyclonal Images
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Immunochemical staining of human olig-2 in human brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
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Anti-OLIG2 rabbit polyclonal antibody at 1:500 dilution
Lane A: Jurkat Whole Cell Lysate
Lysates/proteins at 30 μg per lane.Secondary
Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.
Developed using the Odyssey technique.Performed under reducing conditions.
Predicted band size:32 kDaObserved band size:36 kDa
Anti-Olig2 Antibody, Rabbit Polyclonal: Synonyms
Anti-BHLHB1 Antibody; Anti-bHLHe19 Antibody; Anti-OLIGO2 Antibody; Anti-PRKCBP2 Antibody; Anti-RACK17 Antibody
Olig2 Background Information
Olig2, also known as Oligo2, is a basic helix-loop-helix transcription factor that is expressed in oligodendroglial tumors of the brain. Oligo2 is structurally similar to OLIG1. Both of them have non-overlapping developmental functions in patterning, neuron subtype specification, and the formation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Its over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in down syndrome. Olig2 may be a cause of a form of T-cell acute lymphoblastic leukemia.
Full Name
oligodendrocyte transcription factor 2
References
- Wang J, et al., 2000, Proc Natl Acad Sci. 97(7): 3497-502.
- Lu QR, et al., 2001, Proc Natl Acad Sci. 98(19): 10851-6.
- Marie Y, et al., 2001, Lancet. 358(9278): 298-300.
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