Anti-IL18R1 Antibody (FITC)

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Anti-IL18R1 Antibody (FITC) (Mouse Monoclonal antibody) General Information

Product name
Anti-IL18R1 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human IL18R1
Immunogen
Recombinant Human IL18R1 protein (Catalog#11102-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL18R1 (rh IL18R1; Catalog#11102-H08H; NP_003846.1; Met1-Arg329) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG2a Clone #17
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
5 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-IL18R1 Antibody (FITC) (Mouse Monoclonal antibody) Images

Flow cytometric analysis of Human IL18R1(CD218a) expression on human whole blood granulocytes. Cells were stained with FITC-conjugated anti-Human IL18R1(CD218a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.

Anti-IL18R1 Antibody (FITC): Synonyms

Anti-CD218a Antibody; Anti-CDw218a Antibody; Anti-IL-1Rrp Antibody; Anti-IL18RA Antibody; Anti-IL1RRP Antibody

IL18R1 Background Information

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.
Full Name
interleukin 18 receptor 1
Research Areas
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
References
  • Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
  • Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
  • Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.

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