GAPDH Loading Control Antibody, Rabbit Mab

EliteRmab®, manufactured by recombinant technology
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GAPDH Loading Control Antibody, Rabbit Mab General Information

Product name
GAPDH Loading Control Antibody, Rabbit Mab
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human GAPDH
Immunogen
A synthetic peptide corresponding to the center region of the human GAPDH
Preparation
This antibody was obtained from a rabbit immunized with A synthetic peptide corresponding to the center region of the human GAPDH.
Source
Monoclonal Rabbit IgG Clone #005
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

GAPDH Loading Control Antibody, Rabbit Mab Validated Applications

Application Dilution
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

GAPDH Loading Control Antibody, Rabbit Mab Images

Immunochemical staining of human GAPDH in human hepatitis with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human GAPDH in human appendicitis with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Citation List

GAPDH Loading Control Antibody, Rabbit Mab: Synonyms

Anti-G3PD Antibody; Anti-GAPD Antibody; Anti-HEL-S-162eP Antibody

GAPDH Background Information

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions.
Full Name
glyceraldehyde-3-phosphate dehydrogenase
Research Areas
References
  • Hara MR, et al. (2006) Neuroprotection by pharmacologic blockade of the GAPDH death cascade. PNA. 103 (10): 3887-9.
  • Hara MR, et al. (2006) GAPDH as a sensor of NO stress.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762 (5): 502-9.
  • Tarze A, et al. (2007) GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilizationGAPDH and apoptosis. Oncogene. 26: 2606-20.
  • Yi MK, et al. (2000) Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function. Journal of Virology. 74 (14) : 6459-68.

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