Anti-CD160 Antibody, Mouse Monoclonal
Cat: 12191-MM09
Anti-CD160 Antibody, Mouse Monoclonal General Information
Product name
Anti-CD160 Antibody, Mouse Monoclonal
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CD160
Immunogen
Recombinant Human CD160 / NK1 / BY55 Protein (Catalog#12191-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD160 / NK1 / BY55 (rh CD160 / NK1 / BY55; Catalog#12191-H08H; NP_008984.1; Met1-Leu158). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG2b Clone #09
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-CD160 Antibody, Mouse Monoclonal Validated Applications
| Application | Dilution |
|---|---|
| FCM | 1:25-1:100 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-CD160 Antibody, Mouse Monoclonal Images
Flow cytometric analysis of Human CD160 expression on human whole blood lymphocytes. Cells were stained with purified anti-Human CD160, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Anti-CD160 Antibody, Mouse Monoclonal: Synonyms
Anti-BY55 Antibody; Anti-NK1 Antibody; Anti-NK28 Antibody
CD160 Background Information
CD16 antigen, also known as Natural killer cell receptor BY55 and CD16, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD16 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD16 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD16 is expressed in spleen, peripheral blood, and small intestine. Expression of CD16 is restricted to functional NK and T cytotoxic lymphocytes. CD16 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD16+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD16+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD16 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
- Cancer Immunotherapy
- Co-inhibitory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Detection: Antibodies
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: FCM Antibodies
- Immune Checkpoint Detection: IHC Antibodies
- Immune Checkpoint Targets
- Immunotherapy
- Targeted Therapy
Full Name
CD160 molecule
Research Areas
References
- Barakonyi A. et al., 2004, J Immunol.173 (9): 5349-54.
- Rabot M. et al., 2006, Transpl Immunol. 17 (1): 36-8.
- Abecassis S. et al., 2007, J Invest Dermatol. 127?(5): 1161-6.
- Giustiniani J.?et al., 2007, J Immunol. 178 (3): 1293-300.
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