Anti-Endoglin/CD105 Antibody (HRP), Mouse Monoclonal
Cat: 10149-MM11-H
Cat: 10149-MM11-H
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Anti-Endoglin/CD105 Antibody (HRP), Mouse Monoclonal General Information
Product name
Anti-Endoglin/CD105 Antibody (HRP), Mouse Monoclonal
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Endoglin/CD105
Immunogen
Recombinant Human CD105 protein (Catalog#10149-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Endoglin / CD105 (rh CD105; Catalog#10149-H08H; Met 1-Gly 586; NP_001108225.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP).
Source
Monoclonal Mouse IgG2b Clone #4A3G3D3
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
HRP
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-Endoglin/CD105 Antibody (HRP), Mouse Monoclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 0.1-1 μg/ml |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-Endoglin/CD105 Antibody (HRP), Mouse Monoclonal: Synonyms
Anti-END Antibody; Anti-HHT1 Antibody; Anti-ORW1 Antibody
Endoglin/CD105 Background Information
Endoglin, also known as CD15, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
Full Name
endoglin
Research Areas
References
- Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
- Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
- Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.
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