Anti-CD40 Ligand Antibody, Rabbit Polyclonal

Price:
Size:
Number:

Anti-CD40 Ligand Antibody, Rabbit Polyclonal General Information

Product name
Anti-CD40 Ligand Antibody, Rabbit Polyclonal
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CD40 Ligand
Immunogen
Recombinant Human CD40 Ligand Protein (Catalog#10239-H08E)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD40 Ligand (rh CD40 Ligand; Catalog#10239-H08E; NP_000065.1; Glu108-Leu261). CD40 Ligand specific IgG was purified by Human CD40 Ligand affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD40 Ligand Antibody, Rabbit Polyclonal Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD40 Ligand Antibody, Rabbit Polyclonal: Synonyms

Anti-CD154 Antibody; Anti-CD40 Ligand Antibody; Anti-CD40L Antibody; Anti-gp39 Antibody; Anti-hCD40L Antibody; Anti-HIGM1 Antibody; Anti-IGM Antibody; Anti-IMD3 Antibody; Anti-T-BAM Antibody; Anti-TNFSF5 Antibody; Anti-TRAP Antibody

CD40 Ligand Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD154, also known as CD40 ligand or CD40L, is a member of the TNF superfamily. While CD154 was originally found on T cell surface, its expression has since been found on a wide variety of cells, including platelets, mast cells, macrophages and NK cells. CD154's ability is achieved through binding to the CD40 on antigen-presenting cells (APC). In the macrophage cells, the primary signal for activation is IFN-γ from Th1 type CD4 T cells. The secondary signal is CD40L on the T cell, which interacting with the CD40 molecules, helping increase the level of activation.
Full Name
CD40 ligand
Research Areas
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Grewal IS, et al. (1998) CD40 and CD154 in cell-mediated immunity. Annual Review of Immunology. 16: 111-35.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

Add to Cart Successfully Add to Cart Failed Shopping cart is being updated, please wait U.S.A.