Anti-CD20 Antibody

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Anti-CD20 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-CD20 Antibody
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CD20
Immunogen
E. coli-derived Human CD20/MS4A1 fragment
Preparation
Produced in rabbits immunized with E. coli-derived Human CD20/MS4A1 fragment, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Anti-CD20 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
IHC-P 1:200-1:1000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD20 Antibody (Rabbit Polyclonal antibody) Images

Immunochemical staining of human CD20 in human spleen with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.

Anti-CD20 Antibody: Alternative Names

Anti-B1 Antibody; Anti-Bp35 Antibody; Anti-CD20 Antibody; Anti-CVID5 Antibody; Anti-LEU-16 Antibody; Anti-MS4A1 Antibody; Anti-MS4A2 Antibody; Anti-S7 Antibody

CD20 Background Information

CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Full Name
membrane-spanning 4-domains, subfamily A, member 1
References
  • Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
  • Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
  • Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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