ABL Kinase-enzyme

Two non receptor tyrosine kinases, ABL1 and ABL2, belong to ABL kinase family. Both kinases not only share overlapping biological functions but also have unique roles in cellular processes. Results from knock-out mice have supported their redundant functions. ABL1 and ABL2 double knock-out mice are embryonic lethal, which suggests and crucial role of ABL kinase family in development.

Both ABL family kinases contain a SH2 and SH3 domain at the N-terminus, which are followed by the catalytic kinase domain. A conserved F-actin binding domain is located the carboxyl terminus of ABL1 and ABL2. Since ABL1 has three nuclear localization signal and one nuclear export signal, ABL1 is located in both nucleus and cytoplasm. However, due to the absence of nuclear localization signal, ABL2 is primarily located to the cytoplasm.

The activities of ABL family kinases are tightly regulated. SH2 and SH3 domain negatively regulate ABL kinase activity through binding between SH3 and polyproline-containing linker sequences. Generation of BCR-ABL1 fusion caused by chromosome translocation leads to constitutive kinase activity.

ABL Kinase list
c-Abl/ABL1 ARG1/Arginase 1 ARG2/Arginase II
Enzymes | Proteases | Kinases
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Protein Kinase Introduction
Protein kinase classified by catalytic domains
Protein kinase classified by substrates+
- Tyrosine Kinase
- tyrosine-kinase like group of kinases
- Receptor Tyrosine Kinase (RTKs)
- Non-Receptor Tyrosine Kinase (PTKS)
Janus Kinase-JAK
Focal adhesion Kinase-FAK
TEC Kinase
SRC Kinase
ABL Kinase
Spleen tyrosiine Kinase-SYK
Fyn-related kinase-FRK
FES Kinase
C-terminal Src kinase-CSK
ACK Kinase
- Serine Threonine Kinase
- Histidine Kinase-HK
Protein Kinase Inhibitor
Dual specificity kinase
Intracellular Kinases
Protein kinase related to signaling pathway
Protein Kinase in the Akt Pathway
Protein Kinase in Apoptosis Regulation
Lipid Kinase
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