TCL1A (Protein | Antibody | cDNA Clone | ELISA Kit)

All TCL1A reagents are produced in house and quality controlled, including 1 TCL1A Gene, 1 TCL1A Protein. All TCL1A reagents are ready to use.

TCL1A Protein (1)

    TCL1A cDNA Clone (1)


    In expression vector

    TCL1A Background

    T-cell leukemia/lymphoma protein 1A (abbreviated for TCL1A) is a member of the TCL1 family. TCL1 protooncogene is expressed in CD3-CD4-CD8- precursor T cells and is extinguished at the CD4+CD8+ stage of thymocyte development. In B cells, TCL1 is first expressed in pro-B cells and remains high in naive mantle zone B cells of peripheral lymphoid tissues. The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. It has been demonstrated that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas. All TCL1 isoforms bind to the Akt pleckstrin homology domain. Both in vitro and in vivo TCL1 increases Akt kinase activity and as a consequence enhances substrate phosphorylation. In vivo, TCL1 stabilizes the mitochondrial transmembrane potential and enhances cell proliferation and survival. It has been shown that TCL1 is a novel Akt kinase coactivator, which promotes Akt-induced cell survival and proliferation.

    TCL1A References

    • Jarmo Laine, et al. (2000) The Protooncogene TCL1 Is an Akt Kinase Coactivator. Molecular Cell. 6(2): 395-407.
    • Virgilio L, et al. (1994) Identification of the TCL1 gene involved in T-cell malignancies. PNAS December. 91(26): 12530-4.
    • Hoyer KK, et al. (2002) Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci U S A. 99(22): 14392-7.

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