Anti-Psoriasin / S100A7 Antibody

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Anti-Psoriasin / S100A7 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-Psoriasin / S100A7 Antibody
Validated applications
WB,ELISA,IHC-P
Species reactivity
Reacts with: Human
Not React with: Mouse, Rat
Specificity
Human Psoriasin / S100A7
Immunogen
Recombinant Human S100A7 protein (Catalog#11141-HNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Human S100A7 (rh S100A7; Catalog#11141-HNAE; NP_002954.2; Met 1-Gln 101). S100A7 specific IgG was purified by Human S100A7 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Psoriasin / S100A7 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
WB 1:500-1:2000
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Psoriasin / S100A7 Antibody (Rabbit Polyclonal antibody) Images

Immunochemical staining of human S100A7 in human tonsil with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to tonsil crypt and epithelium. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Immunochemical staining of human S100A7 in human skin with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to sweat gland. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Anti-S100A7 rabbit polyclonal antibody at 1:500 dilution

Lane A: A431 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:11 kDa

Observed band size:15 kDa

Anti-Psoriasin / S100A7 Antibody: Alternative Names

Anti-PSOR1 Antibody; Anti-S100A7c Antibody

Psoriasin / S100A7 Background Information

Protein S1-A7, also known as S1 calcium-binding protein A7, Psoriasin, S1A7, and PSOR1, is a secreted protein which belongs to theS-1 family. S1A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S1A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S1A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype.
Full Name
S100 calcium binding protein A7
References
  • Miyasaki, KT. et al., 1993, J. Dent. Res. 72: 517-23.
  • Watson, PH. et al., 1998, Int J Biochem Cell Biol  30 (5):567-71.
  • Emberley, ED. et al., 2004, Breast Cancer Res  6 (4): 153-9.
  • Ohuchida, K. et al., 2006, Clin Cancer Res  12 (18):5417-22.
  • Kouno, T. et al., 2008, J Pept Sci. 14 (10):1129-38.
  • León, R. et al., 2009, Biochemistry. 48 (44): 10591-600.
  • Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis
    Author
    Lei, H;Li, X;Jing, B;Xu, H;Wu, Y;
    Year
    2017
    Journal
    PLoS ONE
    Application
    ELISA

Standard Antibody Development Service

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Mouse MAb

Rabbit PAb

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Mouse MAb

Rabbit PAb

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