Anti-S100A3 Antibody

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Anti-S100A3 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-S100A3 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human S100A3
Immunogen
Recombinant Human S100A3 protein (Catalog#11136-H10E)
Preparation
Produced in rabbits immunized with purified, recombinant Human S100A3 (rh S100A3; Catalog#11136-H10E; P33764; Met 1-Gln 101). S100A3 specific IgG was purified by Human S100A3 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-S100A3 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-S100A3 Antibody (Rabbit Polyclonal antibody) Images

Immunochemical staining of human S100A3 in human tonsil with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The image showing positive staining in tonsil crypt.
Immunochemical staining of human S100A3 in human skinl with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The image showing positive staining in hair follicle and sebaceous gland.

Anti-S100A3 Antibody: Alternative Names

Anti-S100E Antibody

S100A3 Background Information

Protein S1-A3, also known as Protein S-1E, S1 calcium-binding protein A3, S1A3 and S1E, is a member of the S-1 family. S1A3 / S1E contains 2EF-hand domains. S1A3 / S1E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S1A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation. S1A3 / S1E is a unique member of the Ca2+-binding S1 protein family with the highest cysteine content and affinity for Zn2+. S1A3 / S1E binds both calcium and zinc. S1A3 / S1E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S1A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S1A3 / S1E is a unique protein among all members of the calcium-binding S1 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S1A3 / S1E is released from hair fibers and possibly destabilizes the hair tissue architecture.
Full Name
S100 calcium binding protein A3
References
  • Kizawa, K. et al., 2008, J Biol Chem. 283 (8):5004-13.
  • Kizawa, K. et al., 1998, J Invest Dermatol. 111 (5):879-86.
  • Kizawa, K. et al., 2002, Biochem Biophys Res Commun. 299 (5):857-62.
  • Fritz,G. et al., 2002, J Biol Chem. 277 (36):33092-8.
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